It's Inauguration Day!
Congratulations, Matt vandenBerg, OWU's 17th President!
View details for Inauguration Day and stream the event live.
Congratulations, Matt vandenBerg, OWU's 17th President!
View details for Inauguration Day and stream the event live.
Project Title: Progress Toward the Total Synthesis of Cryptocaryol A
Students: Erin Boedicker ’17 and Zhiyao Li ’17
Mentor: Dr. Mark Mitton-Fry
Cryptocaryol A is a stereochemically complex natural product with potential anticancer properties. A convergent, stereoselective, and concise (11-step) total synthesis has been devised, and progress toward the completion of this synthesis is reported. The stereocenters have been installed using a combination of asymmetric allylation using Leighton's reagent and internal stereorelay. Key steps include an asymmetric bis-allylation, terminus differentiation via ring-closing metathesis, a chemoselective alkene oxidation using ozone, and a boron aldol reaction with 1,5-anti stereoinduction.