Professor of Zoology
B.A., Lawrence University
Ph.D., University of Kansas
Danielle Hamill teaches courses in genetics, animal development, cell biology, and developmental genetics. Her research involves studying cell division and development in roundworms. Her goal is to better understand the process of cell division and, perhaps, to shed light on problems with cell division seen in cancers. She conducted a genetic screen for mutants defective in cell division and currently is characterizing several of these mutants using a combination of genetic, molecular, and microscopic techniques. Hamill also serves as the pre-physical therapy advisor.
For more information about Danielle Hamill, view her Curriculum Vitae.
Areas of Interest / Expertise
The Hamill lab uses the roundworm, Caenorhabditis elegans, to study cell division and developmental processes. Cell division is a complicated process that must by exquisitely regulated, as improper control can result in cancer. Hamill conducted a genetic screen for mutants defective in cell division. Her lab is characterizing several of these mutants using a combination of genetic, molecular, and microscopic techniques. The Hamill lab also has begun studying these processes in other nematodes. What they learn from studying cell division and development in worms will likely provide a better understanding of these important processes in other organisms as well.
- Cell biology
- Cell division and cancer
- Biological development
Publications / Presentations
- Alex J. Rodriguez, Susan A. Seipel, Danielle R. Hamill, Daniele P. Romancino, Marta Di Carlo, Kathy A. Suprenant, and Edward M. Bonder (2005). Seawi – a sea urchin piwi/argonatue family member is a component of MT-RNP complexes. RNA 11(5), 646–656.
- Danielle R. Hamill, Aaron F. Severson, J. Clayton Carter, and Bruce Bowerman (2002). Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains. Developmental Cell 3, 673–684.
- Thimo Kurz, Lionel Pintard, John H. Willis, Danielle R. Hamill, Pierre Gonczy, Matthias Peter, and Bruce Bowerman. (2002). Regulation of microfilament and microtubule function by the Nedd8/Rub1p ubiquitin-like conjugation pathway in C. elegans. Science 295, 1294–1298.
- Sandra E. Encalada, Paula R. Martin, Jennifer A. Phillips, Rebecca Lyzcak, Danielle R. Hamill, Kathryn A. Swan, and Bruce Bowerman (2000). DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Developmental Biology 228(2),225–238.
- Andy Golden, Penny L. Sadler, Matthew R. Wallenfang, Jill M. Schumacher, Danielle R. Hamill, Gayle Bates, Bruce Bowerman, Geraldine Seydoux, and Diane C. Shakes (2000). Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans. Journal of Cell Biology 151(7), 1469–1482.
- Aaron F. Severson, Danielle R. Hamill, J. Clayton Carter, Jill Schumacher, and Bruce Bowerman (2000). The Aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at methaphase and is required for cytokinesis. Current Biology 10(19), 1162–1171.
- Verna Jantsch-Plunger, Pierre Gönczy, Alper Romano, Heinke Schnabel, Danielle Hamill, Ralf Schnabel, Anthony A. Hyman, and Michael Glotzer (2000). CYK-4: A Rho family GTPase activating protein (GAP) required for central spindle formation and cytokinesis. Journal of Cell Biology 149(7), 1391–1404.