David D. Markwardt
Herbert L. and Margaret Wright DuPont Endowed Professorship in Biological Sciences
B.S., Ph.D., University of Wisconsin-Madison
NIH Postdoctoral Fellowship (Genetics), University of Wisconsin-Madison
David Markwardt serves as the Biomedical Engineering Major advisor here at OWU. He also acts as a liaison between the academic and athletic parts of campus in his role as Faculty Athletics Representative (FAR). Markwardt likes to go hiking with his wife, Rachel, and kids, Anna and Henry. In addition, he is a big fan of Wisconsin sports teams and an avid reader (mostly post-apocalyptic fiction and stories about big-wave surfing).
Areas of Interest / Expertise
- Cell and molecular biology
- Molecular biotechnology
Work in our lab falls into two distinct areas. The first is a joint project between the Markwardt and Kelly research groups studying the effects of exercise on tumorigenesis in the colon. Research techniques used in this project include animal husbandry, mouse colonoscopy, immunological assays, histology, and molecular analysis of colon and tumor tissues. The second area is broadly centered on the biology of ribonucleic acid (RNA). Specifically, we are interested in how cells control gene expression by regulating the metabolism, processing, and translation of RNA. To study these processes, we use the fission yeast Schizosaccharomyces pombe and the soil nematode Caenorhabditis elegans. For this project we use a wide variety of fundamental molecular tools and techniques, including: PCR, reverse-transcription (RT)-PCR, real-time (quantitative)-PCR, gene sequencing, bioinformatics, microbiological cell culture, DNA/RNA/protein analysis, gene cloning, and microarray analysis.
Publications / Presentations
- Laabs, T.L.*, Markwardt, D.D.*, Slattery, M.G., Newcomb, L.L., Stillman, D.J., and Heideman, W. (2003) ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 100:10275–10280. *T.L.L. and D.D.M. contributed equally to this work.
- Hall, D.D., Markwardt, D.D., Parviz, F., and Heideman, W. (1998) Regulation of the Cln3-Cdc28 kinase by cAMP in Saccharomyces cerevisiae. EMBO J., 17(15); 4370–4378.
- Parviz, F., Hall, D.D., Markwardt, D.D., and Heideman, W. (1998) Transcriptional regulation of CLN3 expression by glucose in Saccharomyces cerevisiae. J. Bacteriol., 180(17); 4508–4515.
*Indicates an undergraduate author.