Assistant Professor of Neuroscience, Psychology
B.A., Kenyon College
Ph.D., Mayo Clinic
Chelsea Vadnie joined the faculty at Ohio Wesleyan University in the fall of 2020. She received her undergraduate degree in Neuroscience at Kenyon College and her Ph.D. in Neurobiology of Disease at the Mayo Clinic (Rochester, MN) in the lab of Doo-Sup Choi. Her dissertation focused on using mouse models to understand the role of neurotensin signaling in mania-like behavior. Dr. Vadnie then completed a postdoctoral fellowship in Colleen McClung’s lab within the T32 Translational Research Training in Sleep Medicine Program at the University of Pittsburgh to gain expertise in sleep and circadian science.
Chelsea Vadnie is interested in using mouse models to study the role of circadian rhythm disruptions in behaviors relevant to anxiety, mood and alcohol use disorders. She uses optogenetics and environmental manipulations to understand whether circadian rhythm disruption alters behavioral phenotypes and neurobiology in mouse models. Her current project is centered on determining the role of the central pacemaker in the brain, the suprachiasmatic nucleus, in the regulation of mood and anxiety-like behavior. She also studies the behavioral and neurobiological effects of circadian disruption during adolescence.
Jia YF, Vadnie CA, Ho AM, Peyton L, Veldic M, Wininger K, Matveyenko A, Choi DS. (2019). Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms. Addict Biol. e12801. doi: 10.1111/adb.12801.
Vadnie CA, McClung CA. (2017). Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus. Neural Plast. 2017:1504507. doi: 10.1155/2017/1504507.
Vadnie CA, Ayers-Ringler J, Oliveros A, Abulseoud OA, Choi S, Hitschfeld MJ, Choi DS. (2016). Antipsychotic-like effects of a neurotensin receptor type 1 agonist. Behav Brain Res. 305:8-17. doi: 10.1016/j.bbr.2016.02.019.
Vadnie CA, Park JH, Abdel Gawad N, Ho AM, Hinton DJ, Choi DS. (2014). Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. Front Neurosci. 8:288. doi: 10.3389/fnins.2014.00288.
Vadnie CA, Hinton DJ, Choi S, Choi Y, Ruby CL, Oliveros A, Prieto ML, Park JH, Choi DS. (2014). Activation of neurotensin receptor type 1 attenuates locomotor activity. Neuropharmacology. 85:482-92. doi: 10.1016/j.neuropharm.2014.05.046.