Neuroscience

NEUR 300.1.    Introduction to Neuroscience (Ambegaokar; Bailey)
An introduction to the study of neuroscience through the Molecular & Cellular, Behavioral & Cognitive, and Computational sub-fields. Fundamental principles of neuronal electrochemical properties, neuronal communication, and brain structure will be explored to allow discussion of larger themes such as Memory & Cognition, Biological Rhythms & Sleep, and Neurobehavioral Disorders. This course exposes students to the unique but complementary research methods that each sub-field uses in addressing questions in neuroscience. Lecture and laboratory (fused lecture/lab format where laboratory exercises are interspersed with lecture material). Prerequisites: 2 of the following 3 courses: BIOL 120, PSYC 110, or CHEM 110; or by permission of the instructor. Fall.

NEUR/MATH 300.3.    Dynamical Systems in Neuroscience (Pyzza)
A mathematical modeling course focusing on dynamical systems with applications in neuroscience. Topics include equilibria, bifurcations, phase plane analysis, limit cycles, and numerical integration techniques. Neuroscience examples will be taken from Hodkin-Huxley, integrate-and-fire, and firing-rate models. Prerequisite: MATH 280 or permission of instructor. Fall.

NEUR 300.9.    Neurobehavioral Genetics (Ambegaokar)
The improvement in molecular and statistical genetics over the last 25 years has lead to numerous insights into complex neurological and psychiatric disorders that have been known but not understood for several decades. This course will discuss the pathophysiology of genes linked to or associated with Alzheimer's, Parkinson's, frontotemporal dementia and other neurodegenerative diseases. We will also discuss progress in discovering genes associated with schizophrenia, autism and other psychiatric disorders, and the use of clinical subphenotypes or "endophenotypes" to aid in this research. Finally, we will discuss the design and validity of genetically engineered animal models for these diseases, the design of genome-wide association studies (GWAS), and the latest methodologies in high-throughput sequencing. This is designed for students with an interest in neuroscience or genetics. Lecture only. Prerequisites: NEUR 300.1; or BIOL 120, PSYC 110 and BIOL 271; or consent of instructor. Fall.

NEUR 300.12.    Molecular & Cellular Neuroscience (Ambegaokar)
The course examines the fundamental molecular and cellular properties of neurons and other cells of the nervous system. Topics include biochemical properties of ion channels, neurotransmitters and their receptors; signaling cascades and genetic regulation; synaptic transmission and synaptic plasticity (the cellular basis of learning & memory); neuronal development and developmental disorders; neural stem cells; and sensory receptors (vision, olfaction, taste, touch, temperature, pain, hearing & balance). The lab portion includes molecular biology techniques, the use of in vitro and in vivo model systems, and bioinformatics. Lecture and laboratory. NEUR 300.1 or BIOL 271; CHEM 111 (CHEM 260 recommended); or by permission of instructor. Spring.

NEUR 323.    Computational Neuroscience (Fink; Pyzza)
An introduction to computational modeling of neural systems and neural data analysis techniques for students majoring in neuroscience. Topics include models of the individual neuron, neural encoding and decoding of sensory information, information processing by neural networks, models of memory formation, time-frequency analysis of neural signals, and image processing techniques. Lecture and laboratory. Prerequisite: NEUR 300.1 and one of CS 110, MATH 105, MATH 110, MATH 230, or PSYC 210; or permission of instructor. Spring.

INT 300 11.  Neuroanatomy (Yates)
This course provides an introduction to the anatomy and function of the human nervous system. Emphasis will be on the gross structure and function of the cerebrum, brainstem and cranial nerves and spinal cord and spinal nerves. Descriptions of alterations in normal anatomy through disease or injury will reinforce the significance of the anatomical structure/function relationships. Lecture and laboratory. Prerequisite: one introductory ZOOL course. Summer.

PHYS 330.    Biophysics of the Brain (Fink)
This course takes a theoretical approach to investigating brain function over a wide range of spatial scales, from individual neuronal ion channels to networks of thousands of neurons. Topics include the biophysics of ion flow, excitable membranes, action potential generation, signal propagation, and synaptic transmission; the collective dynamics of networks of neurons and the biological functions served by such neuronal activity; neuronal encoding and processing of sensory information, as well as strategies for decoding neuronal representations (the basis for brain-machine interfaces); and plasticity mechanisms, with applications to memory formation. Investigation of all topics will be conducted using mathematical models of varying levels of complexity. Lecture and laboratory. Prerequisite: CS 110 and MATH 280, or permission of instructor. Spring.

PSYC 300.15.    Cognitive Neuroscience (Bailey)
This course explores the cognitive and neural processes that support perception, attention, memory, social cognition, language, executive function, and decision making. It will explore the evolution and development of the neural structures that underlie these cognitive processes. Students will gain experience with cognitive neuroscience experimental techniques including behavioral and electrophysiological methods of research. An optional laboratory (PSYC 300.19) is available (required for Neuroscience majors).  Prerequisites: C- or better in PSYC 110 and 2 Tier 2 PSYC courses; or NEUR 300.1; or permission of instructor. Spring.

PSYC 300.16.    Affective Neuroscience (Bailey)
This course explores the neural processes that give rise to affect and emotion. Emphasis will be on mapping affective experience and behavior to brain function. Both human and animal literature will be surveyed, and relevant areas covered will include basic theories of emotion, neural circuitry of emotion, fear learning and memory, emotion regulation, and reward. Lecture only. Prerequisites: C- or better in either PSYC 110 and two Tier 2 psychology courses; or C- or better in NEUR 300.1; or permission of instructor. Fall.

PSYC 343.    Behavioral Neuroscience (Yates)
Introduction to the biological mechanisms and neural processes underlying behavior, sensory functions, and internal regulation. No previous biological background necessary. The emphasis is on the relationship of neurophysiology to such basic processes as arousal, attention, motivation, learning, memory, abnormal behavior, and perception. An optional laboratory (PSYC 344) is available (required for Neuroscience majors). Prerequisites: C- or better in NEUR 300.1 or PSYC 110; or permission of instructor. Fall.

PSYC 345.    Psychopharmacology (Yates)
This course will involve consideration of the relationships among drugs, the nervous system, conscious experience, and behavior. The history, as well as the psychopharmacology, of a wide variety of licit and illicit substances is surveyed including alcohol, nicotine, caffeine, cocaine, amphetamines, marijuana, psychedelics, opiates, and prescription drugs. Lecture only. Prerequisites: C- or better in NEUR 300.1 or PSYC 110; or permission of instructor. Spring.

PSYC 374.    Topics in Neuroscience (Yates)
In-depth examination of selected activities of the nervous system with particular emphasis on an understanding of the relationships between neuroanatomy, physiology, biochemistry, and behavior. Topics such as sleep disorders, memory, obesity, reproductive behavior, and hemispheric dominance will be examined using a neurobiological approach. Prerequisites: C- or better PSYC 110 and 343 or a strong biological background. Spring.

490. Independent Study (all Faculty, all departments)

491. Directed Readings (all Faculty, all departments)

499. Seminars (all Faculty, all departments)